Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The evolution of virulence

A F Read1

  • 1Institute of Cell, Animal and Population Biology, University of Edinburgh, UK.

Trends in Microbiology
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

Understanding the variation in infectious disease virulence requires examining both cellular mechanisms and evolutionary pressures. This research explores the selective forces shaping genes related to pathogen virulence and host-pathogen genetic contributions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The fitness of drug-resistant malaria parasites in a rodent model: multiplicity of infection.

Journal of evolutionary biology·2011
Same author

Partitioning regulatory mechanisms of within-host malaria dynamics using the effective propagation number.

Science (New York, N.Y.)·2011
Same author

Comparative biology and disease ecology.

Trends in ecology & evolution·2011
Same author

Counting the cost of disease resistance.

Trends in ecology & evolution·2011
Same author

A lively bustle.

Trends in ecology & evolution·2011
Same author

Catching the Red Queen? The advice of the Rose.

Trends in ecology & evolution·2011
Same journal

Host membranes provide hidden gateways for 'accidental pathogens'.

Trends in microbiology·2026
Same journal

Structural inequalities in global antimicrobial resistance governance.

Trends in microbiology·2026
Same journal

Environmental microbes as modulators of plant volatile landscapes: Implications for plant-insect chemical communication.

Trends in microbiology·2026
Same journal

Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools.

Trends in microbiology·2026
Same journal

Cronobacter spp.

Trends in microbiology·2026
Same journal

Anaerobic lignin deconstruction: A game changer for lignocellulosic biorefineries.

Trends in microbiology·2026
See all related articles

Area of Science:

  • Evolutionary biology
  • Microbiology
  • Genetics

Background:

  • Virulence variation in infectious diseases impacts host and pathogen evolution.
  • Understanding virulence requires integrated cellular, molecular, and evolutionary perspectives.

Purpose of the Study:

  • To investigate the evolutionary factors driving variation in infectious disease virulence.
  • To analyze the selective pressures acting on genes influencing virulence.

Main Methods:

  • Review of existing literature on virulence evolution.
  • Analysis of host-pathogen genetic interactions.
  • Theoretical modeling of selection on virulence genes.

Main Results:

  • Virulence is shaped by complex selective landscapes.

Related Experiment Videos

  • Host immune responses and pathogen transmission strategies are key drivers.
  • Trade-offs between pathogen replication and transmission influence virulence levels.

    • Conclusions:

    • Evolutionary explanations are crucial for understanding virulence.
    • Selection acts on virulence genes, influencing host-pathogen coevolution.
    • Further research should integrate molecular and evolutionary approaches.