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[Cluster headache with a familial presentation]

R Alberca1, J M Aguilera, J L Casado

  • 1Servicio de Neurología, Hospital Universitario Virgen del Rocío, Sevilla.

Neurologia (Barcelona, Spain)
|January 1, 1994
PubMed
Summary
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Familial cluster headache (CH) presentation occurred in 4 of 190 patients. This suggests a higher prevalence among relatives, hinting at potential genetic factors in cluster headache.

Area of Science:

  • Neurology
  • Genetics

Background:

  • Cluster headache (CH) is a debilitating neurological disorder.
  • The familial occurrence of CH is not well-established.

Purpose of the Study:

  • To investigate the familial aggregation of cluster headache.
  • To explore potential genetic contributions to CH.

Main Methods:

  • Retrospective analysis of 190 cluster headache patients.
  • Family history documentation for affected individuals.

Main Results:

  • Four out of 190 patients (2.1%) presented with familial cluster headache.
  • Affected relatives included fathers and brothers.
  • One family showed a broader pattern of affected members.

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Conclusions:

  • A higher prevalence of cluster headache appears in relatives of CH patients compared to the general population.
  • The familial aggregation warrants further investigation into potential genetic factors.