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Anaphylatoxin C5a production during short-term submaximal dynamic exercise in man
G Camus1, J Duchateau, G Deby-Dupont
1FNRS, Laboratory of Human Applied Physiology, ISEPK (B21), Sart Tilman, Liège, Belgium.
International Journal of Sports Medicine
|January 1, 1994
Summary
Short-term exercise significantly elevates plasma myeloperoxidase (MPO) and C5a levels, indicating polymorphonuclear neutrophil (PMN) and complement activation. These markers correlated, suggesting C5a
Area of Science:
- Exercise Physiology
- Immunology
- Biochemistry
Background:
- Polymorphonuclear neutrophils (PMNs) and complement activation are implicated in physiological responses to exercise.
- Myeloperoxidase (MPO) and C5a anaphylatoxin serve as specific markers for PMN and complement activation, respectively.
Purpose of the Study:
- To investigate the effects of short-term submaximal exercise on plasma levels of MPO and C5a.
- To explore the relationship between MPO and C5a concentrations during and after exercise.
- To determine if PMN activation is linked to their mobilization during exercise.
Main Methods:
- Eleven healthy young males performed 20 minutes of cycle ergometer exercise at 80% maximal oxygen uptake.
- Plasma MPO and C5a levels were measured at rest, during exercise, and during recovery.
- Circulating PMN counts were also assessed.
Main Results:
- Plasma MPO and C5a concentrations significantly increased during exercise (p < 0.001).
- Both MPO and C5a levels showed a rapid decrease during the recovery period.
- A strong positive correlation (r = 0.651; p < 0.001) was found between MPO and C5a levels, and circulating PMN count increased by 80% (p < 0.001).
Conclusions:
- Short-term submaximal exercise induces significant PMN and complement activation.
- The data suggest a role for complement anaphylatoxin C5a in PMN degranulation during exercise.
- PMN activation during exercise appears independent of their mobilization.