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Cutaneous crystalline deposits in myeloma
R E Jenkins1, E Calonje, H Fawcett
1St John's Institute of Dermatology, St Thomas' Hospital, London, England.
Archives of Dermatology
|April 1, 1994
Summary
This study details a rare initial presentation of multiple myeloma (MM) as crystalline protein deposits in the skin, leading to facial swelling. Treatment of the underlying myeloma resolved these unique cutaneous manifestations.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Multiple myeloma (MM) is a plasma cell malignancy typically presenting with systemic or bone-related symptoms.
- This report describes an unprecedented case where crystalline protein deposition in the skin was the initial clinical manifestation of myeloma.
Observation:
- Extracellular crystalline deposits were identified in dermal and conjunctival tissues, as well as bone marrow.
- Plasma cell infiltration was notably absent in the affected skin areas.
- The patient presented with facial and eyelid swelling attributed to these crystalline deposits.
Findings:
- The study identified crystalline deposits in the skin and conjunctivae as the presenting feature of myeloma.
- The precise mechanisms of crystal formation and localized deposition remain undetermined.
- Resolution of cutaneous crystal deposition occurred following treatment of the primary hematologic disorder.
Implications:
- This case expands the spectrum of initial presentations for multiple myeloma.
- It highlights the importance of considering systemic diseases in cases of unexplained crystalline deposition in the skin.
- Effective management of the underlying myeloma can reverse associated dermatologic findings.