Morphometrical histochemical and biochemical parameters in the dog alloxan diabetes

Changes of morphometrical, biochemical, histochemical and immunohistochemical parameters were investigated in the alloxan diabetes in the dog. Samplings of material for electron microscopical and histochemical examinations were performed in 3 month period (4 times). A significant thickening of capillary basement membranes in the striated muscle (vastus lateralis) was ascertained even in the dog with glucose intolerance only. In this mentioned case a decrease of glucoso-6-phosphatase activity was observed. Evaluation of different types of muscle fibres assigned an increase of slow twitch fibres or intermediate ones respectively.