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Butyrate as a differentiating agent: pharmacokinetics, analogues and current status
H L Newmark1, J R Lupton, C W Young
1Laboratory of Digestive Tract Carcinogenesis, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Cancer Letters
|April 1, 1994
Abstract:
The field of butyrate-induced differentiation of neoplastic and non-neoplastic cells is reviewed and possible clinical correlations considered with regard to butyrate, butyrate prodrugs and butyrate analogues. These topics are discussed from the point of view of the concentrations required in vitro for biologic effect, and likely pharmacokinetic behavior in vivo.