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Basic fibroblast growth factor enhances myocardial collateral flow in a canine model
1Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892.
The American Journal of Physiology
|April 1, 1994
Summary
Basic fibroblast growth factor (FGF) enhances collateral blood flow in dogs with myocardial ischemia. FGF treatment increased blood flow and vessel density, suggesting it aids in healing and angiogenesis.
Area of Science:
- Cardiovascular Research
- Regenerative Medicine
- Molecular Biology
Background:
- Basic fibroblast growth factor (FGF) is implicated in angiogenesis and myocardial healing.
- Coronary collateral formation is crucial for managing ischemic heart disease.
Purpose of the Study:
- To investigate the effect of exogenous basic FGF on collateral blood flow in ischemic myocardium.
- To assess FGF's role in angiogenesis and endothelial cell activity in a canine model.
Main Methods:
- Dogs underwent gradual coronary artery occlusion using Ameroid constrictors.
- Basic FGF or saline was administered daily into the collateral-dependent zone for 28 days.
- Collateral flow was measured weekly via the collateral to normal zone (CZ/NZ) blood flow ratio during vasodilation.
Main Results:
- Basic FGF treatment significantly increased CZ/NZ blood flow ratios compared to controls (0.49 vs. 0.35).
- FGF administration led to increased numerical density of distribution vessels and endothelial cell DNA synthesis.
- Basic FGF demonstrated acute coronary vasodilatory effects.
Conclusions:
- Exogenous basic FGF enhances maximal collateral blood flow in myocardial ischemia.
- The peptide's angiogenic properties likely mediate improved collateral circulation.
- Acute vasodilatory effects may also contribute to FGF's therapeutic potential in ischemic heart disease.