Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple subpial transections in the language cortex

O Devinsky1, K Perrine, B Vazquez

  • 1Department of Neurology, NYU School of Medicine.

Brain : a Journal of Neurology
|April 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective recovery of antimony from Sb-bearing copper concentrates by integration of alkaline sulphide leaching solutions and microwave-assisted heating: A new sustainable processing route.

The Science of the total environment·2024
Same author

Effects of ganaxolone on non-seizure outcomes in CDKL5 Deficiency Disorder: Double-blind placebo-controlled randomized trial.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2024
Same author

Potential of cannabinoids as treatments for autism spectrum disorders.

Journal of psychiatric research·2021
Same author

Painful Cutaneous Syncytial Myoepithelioma: From Nonspecific Symptoms to Histopathologic Diagnosis.

Actas dermo-sifiliograficas·2019
Same author

Neural correlates of unstructured motor behaviors.

Journal of neural engineering·2019
Same author

3T MRI Whole-Brain Microscopy Discrimination of Subcortical Anatomy, Part 2: Basal Forebrain.

AJNR. American journal of neuroradiology·2019
Same journal

Retinal hyper-reflective foci link retinal and cortical pathology in paediatric multiple sclerosis.

Brain : a journal of neurology·2026
Same journal

Two scripts, two pathways: dorsal-ventral biases in post-stroke kana-kanji agraphia.

Brain : a journal of neurology·2026
Same journal

Blood cytotoxic natural killer-like CD8 + CD94+ T cells migrate to the brain and predict multiple sclerosis severity.

Brain : a journal of neurology·2026
Same journal

Time to reconsider risk for psychosis?

Brain : a journal of neurology·2026
Same journal

A descending posterior insular pathway drives sensory hypersensitivity in neuropathic pain.

Brain : a journal of neurology·2026
Same journal

GIT1 loss of function causes a recognizable syndromic neurodevelopmental disorder.

Brain : a journal of neurology·2026
See all related articles

Multiple subpial transections (MST) improved epilepsy control in three patients. While temporary language deficits occurred, long-term seizure freedom or significant reduction was achieved, demonstrating MST

Area of Science:

  • Neurosurgery
  • Epileptology
  • Neurolinguistics

Background:

  • Medically refractory partial epilepsy poses significant treatment challenges.
  • Extra-operative stimulation mapping is crucial for identifying eloquent cortex.
  • Multiple subpial transections (MST) are a surgical option for epilepsy involving critical brain areas.

Observation:

  • Three patients with medically refractory partial epilepsy underwent surgery involving MST in language cortex.
  • Surgical mapping utilized subdural grids over dominant temporal, frontal, and parietal regions.
  • Procedures included anterior temporal lobectomy with posterior MST or frontoparietal MST alone.

Findings:

  • Patients with MST in posterior language cortex experienced transient postoperative language dysfunction, improving by 9 months.

Related Experiment Videos

  • The patient with frontoparietal MST showed immediate improvement in language functions.
  • Two patients with anterior temporal lobectomy and MST achieved seizure freedom at 1-year follow-up.
  • One patient with frontoparietal MST had >70% seizure frequency reduction at 1-year follow-up.

    • Implications:

    • MST can be an effective surgical strategy for epilepsy in or near language areas.
    • Careful mapping and surgical planning are essential to balance seizure control and neurological function.
    • This study suggests MST offers a viable option for intractable epilepsy with potential for functional recovery.