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A new vitreal drug delivery system using an implantable biodegradable polymeric device
H Kimura1, Y Ogura, M Hashizoe
1Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
Investigative Ophthalmology & Visual Science
|May 1, 1994
Summary
Biodegradable polymeric devices show promise for sustained drug delivery to the vitreous humor. These implantable devices demonstrated feasibility and well-tolerated drug release in preclinical studies.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Drug Delivery Systems
Background:
- The vitreous humor presents a challenge for sustained drug delivery due to its rapid clearance.
- Biodegradable polymers offer a potential solution for localized and prolonged drug release within the eye.
Purpose of the Study:
- To assess the feasibility of an implantable biodegradable polymeric device for drug delivery into the vitreous humor.
- To evaluate the drug release kinetics and biocompatibility of these novel devices.
Main Methods:
- Two poly(DL-lactic acid) devices with different molecular weights were fabricated.
- In vitro drug release of sodium fluorescein (NaF) was measured.
- Intravitreal NaF kinetics were studied in rabbits, followed by electrophysiological and histological safety assessments.
Main Results:
- Devices released NaF for over 25 (device-1) and 45 (device-2) days in vitro.
- Detectable NaF concentrations persisted in the vitreous for up to 17 (device-1) and 28 (device-2) days.
- No toxic effects were observed, indicating good biocompatibility.
Conclusions:
- Implantable biodegradable polymeric devices are a potentially effective system for vitreous drug delivery.
- The study supports the development of these devices for sustained ocular drug administration.