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[Primary malignant lymphoma of the urinary bladder]
O Miyake1, M Tsujihata, H Itoh
1Department of Urology, Sumitomo Hospital.
Summary
Primary malignant lymphoma of the urinary bladder is rare. This report details two successful cases treated with chemotherapy, highlighting the potential for curative outcomes and preserved bladder function.
Area of Science:
- Oncology
- Urology
Background:
- Primary malignant lymphoma of the urinary bladder is an uncommon condition.
- Reports in foreign countries total approximately 70 cases, with only 23 documented in Japan.
Observation:
- The first case involved a 64-year-old woman with a history of transitional cell carcinoma, who developed a bleeding bladder tumor diagnosed as diffuse large B-cell non-Hodgkin lymphoma.
- The second case presented a 51-year-old woman with a painless gross hematuria, revealing an intramural bladder tumor diagnosed as diffuse medium B-cell non-Hodgkin lymphoma.
Findings:
- Both patients received chemotherapy (CAP for the first, VEPA for the second) with positive outcomes.
- The first patient has remained disease-free post-treatment.
- The second patient showed no recurrence at a 9-month follow-up.
Implications:
- Malignant lymphoma confined to the bladder can be effectively treated with chemotherapy and/or radiation.
- These treatments offer a curative potential while preserving bladder function.
- Further research into primary bladder lymphoma is warranted given its rarity.