Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Can we learn anything from small trials?

D L Sackett1, D J Cook

  • 1Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Annals of the New York Academy of Sciences
|December 31, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fall Detection in Smart Home Environments Using UWB Sensors and Unsupervised Change Detection.

Journal of reliable intelligent environments·2025
Same author

Brain Charts for the Rhesus Macaque Lifespan.

bioRxiv : the preprint server for biology·2024
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Society of Colon and Rectal Surgeons Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons: Canadian Surgery Forum, London, Ont., Sept. 19 to 22, 2002.

Canadian journal of surgery. Journal canadien de chirurgie·2023
Same author

The Association between Frailty and Short-Term Outcomes in an Intensive Care Unit Rehabilitation Trial: An Exploratory Analysis.

The Journal of frailty & aging·2020
Same author

Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study.

BMC medical research methodology·2017
Same author

The monitoring of activity at home after total hip arthroplasty.

The bone & joint journal·2016
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
Same journal

Synchrony and Reciprocity in Rhythmic Interaction.

Annals of the New York Academy of Sciences·2026
See all related articles

Small clinical trials offer valuable insights, challenging conventional wisdom and identifying optimal therapies. They also provide robust data for meta-analyses, enhancing evidence credibility.

Area of Science:

  • Clinical research methodology
  • Evidence-based medicine
  • Biostatistics

Background:

  • The utility of small clinical trials in medical research is often underestimated.
  • Conventional approaches may not always reflect the most effective therapeutic strategies.

Purpose of the Study:

  • To highlight the significant contributions of small clinical trials to medical knowledge.
  • To demonstrate how small trials can effectively challenge established therapeutic norms.

Main Methods:

  • Analysis of the informational yield from small-scale clinical investigations.
  • Evaluation of the statistical power derived from event-based patient counts in trials.
  • Assessment of the role of small trials in synthesizing evidence through meta-analysis.

Related Experiment Videos

Main Results:

  • Small trials can effectively question untested therapeutic conventions.
  • Certain small trials provide definitive evidence for superior treatments based on event data.
  • Individually inconclusive small trials contribute significantly to conclusive meta-analyses.

Conclusions:

  • Small clinical trials are crucial for advancing therapeutic understanding and practice.
  • The strategic use of small trials enhances the reliability and impact of medical evidence.
  • Meta-analyses integrating data from multiple small trials offer robust and credible findings.