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The temporal bone in multiple myeloma

W Li1, P A Schachern, T Morizono

  • 1University of Minnesota Otitis Media Research Center, Department of Otolaryngology, Minneapolis.

The Laryngoscope
|June 1, 1994
PubMed
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Multiple myeloma frequently affects bones, including the temporal bone. This study details oto-histopathologic changes in temporal bones from multiple myeloma patients, revealing tumor involvement and osteolysis.

Area of Science:

  • Oto-histopathology
  • Skeletal Oncology
  • Hematologic Malignancies

Background:

  • Multiple myeloma is a skeletal malignancy with potential for widespread bone involvement.
  • No prior studies have systematically reported temporal bone findings in multiple myeloma.
  • Understanding these changes is crucial for comprehensive patient care.

Purpose of the Study:

  • To analyze and report the oto-histopathologic changes in temporal bones associated with multiple myeloma.
  • To investigate the extent of tumor infiltration and resultant bone destruction.
  • To document associated middle and inner ear pathologies.

Main Methods:

  • Retrospective analysis of 15 temporal bones from 8 patients diagnosed with multiple myeloma.
  • Detailed oto-histopathologic examination to identify tumor infiltration, osteolysis, and other pathological changes.

Related Experiment Videos

  • Correlation of histopathologic findings with clinical otologic symptoms.

    • Main Results:

    • Tumor involvement of the bone marrow was observed in 13 of 15 temporal bones.
    • Osteolysis was a significant finding, present in 11 temporal bones.
    • Otitis media (serous or purulent) occurred in 13 ears, with mastoid effusions in 12. Inner ear changes, including degeneration of the organ of Corti and labyrinthine hydrops, were seen in 8 ears, most severe in symptomatic patients.
    • Myeloma cell infiltration was not observed in the middle ear mucosa or inner ear structures.

    Conclusions:

    • Multiple myeloma commonly involves the temporal bone marrow, leading to osteolysis and secondary otitis media.
    • While direct myeloma cell invasion of the middle and inner ear appears rare, significant pathological changes can occur.
    • These findings highlight the importance of considering temporal bone involvement in the management of multiple myeloma patients, especially those with otologic symptoms.