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Related Experiment Videos

Bcl-2 expression in normal endometrium during the menstrual cycle

A Gompel1, J C Sabourin, A Martin

  • 1Departement de Gynécologie et Obstétrique, Hôpital Hotel Dieu, Paris, France.

The American Journal of Pathology
|June 1, 1994
PubMed
Summary

Bcl-2 expression in the endometrium varies cyclically, peaking in the follicular phase and decreasing with secretory activity. This suggests hormones regulate Bcl-2, potentially impacting cancer development.

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Area of Science:

  • Oncology
  • Cell Biology
  • Endocrinology

Background:

  • Bcl-2 is a proto-oncogene that inhibits apoptosis, promoting cell survival.
  • The endometrium's hormone-dependent proliferation makes it a model for studying Bcl-2 regulation.

Purpose of the Study:

  • To investigate the cyclic expression of Bcl-2 in normal and hyperplastic endometrium.
  • To determine the hormone dependency of Bcl-2 expression in endometrial tissue.

Main Methods:

  • Immunohistochemical analysis of 53 normal and 5 hyperplastic endometrium samples.
  • Evaluation of Bcl-2 expression throughout the menstrual cycle.

Main Results:

  • Bcl-2 predominantly stained glandular cells, with peak expression at the end of the follicular phase.

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  • Bcl-2 expression decreased at the onset of secretory activity.
  • Cyclic variations in Bcl-2 were observed in stroma, surface epithelium, and arterial vessels.

    • Conclusions:

    • Endometrial Bcl-2 expression is under strong hormone-dependent regulation.
    • Hormonal regulation of Bcl-2 may play a significant role in endometrial tumorigenesis.