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IGF-II producing hepatic fibrosarcoma associated with hypoglycemia
Internal Medicine (Tokyo, Japan)
|December 1, 1993
Summary
A liver fibrosarcoma caused severe hypoglycemia in a 67-year-old male. Tumor removal and embolization resolved the low blood sugar, with Insulin-like Growth Factor-II implicated in the mechanism.
Area of Science:
- Hepatology
- Oncology
- Endocrinology
Background:
- A 67-year-old male presented with recurrent episodes of severe hypoglycemia.
- Symptoms included morning weakness when blood glucose levels dropped below 40 mg/dL.
Observation:
- Imaging revealed a large tumor in the right lobe of the liver.
- The tumor was surgically removed and identified as a fibrosarcoma.
Findings:
- Transcatheter arterial embolization temporarily resolved hypoglycemia.
- Histological examination showed intense staining for Insulin-like Growth Factor-II (IGF-II) in tumor cells.
- IGF-II is suggested to be the causative factor for the tumor-induced hypoglycemia.
Implications:
- This case highlights fibrosarcoma as a rare cause of tumor-induced hypoglycemia.
- The findings suggest IGF-II plays a significant role in the pathogenesis of hypoglycemia associated with this specific tumor type.
- Effective management involved both embolization and surgical resection.