Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Humanized antibodies

G Winter1, W J Harris

  • 1Laboratory of Molecular Biology, MRC Centre for Protein Engineering, Cambridge, UK.

Trends in Pharmacological Sciences
|May 1, 1993
PubMed
Summary
This summary is machine-generated.

Protein engineering advances have created humanized antibodies from rodent monoclonal antibodies. These engineered antibodies offer improved treatment for diseases like cancer and autoimmune disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a sprayable hydrogel formulation for the skin application of therapeutic antibodies.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2019
Same author

Structure determination and crystal chemistry of large repeat mixed-layer hexaferrites.

IUCrJ·2018
Same author

Letter to the Editor.

Radiography (London, England : 1995)·2017
Same author

Preliminary evaluation of cytosine-phosphate-guanine oligodeoxynucleotides bound to gelatine nanoparticles as immunotherapy for canine atopic dermatitis.

The Veterinary record·2017
Same author

Testing and clinical implications for non-V600 BRAF mutations in metastatic NRAS<sup>mt</sup> melanoma.

The British journal of dermatology·2016
Same author

Clinical Research Abstracts of the British Equine Veterinary Association Congress 2015.

Equine veterinary journal·2015
Same journal

Targeting developmental reprogramming: hPSC insights for cancer interception.

Trends in pharmacological sciences·2026
Same journal

July 2026 issue first authors.

Trends in pharmacological sciences·2026
Same journal

Chronobiomaterials for circadian-aligned brain therapeutics.

Trends in pharmacological sciences·2026
Same journal

Biosensors for translatable GPCR bias.

Trends in pharmacological sciences·2026
Same journal

ECM stiffness and epigenetics in organ fibrosis.

Trends in pharmacological sciences·2026
Same journal

Which HTT transcript to lower?

Trends in pharmacological sciences·2026
See all related articles

Area of Science:

  • Biotechnology
  • Immunology
  • Protein Engineering

Background:

  • Hybridoma technology produced rodent monoclonal antibodies, but their clinical use was limited.
  • Rodent antibodies faced challenges with immunogenicity and pharmacokinetics in human patients.

Purpose of the Study:

  • To review advancements in protein engineering for antibody development.
  • To highlight the generation of humanized antibodies for therapeutic applications.

Main Methods:

  • Protein engineering techniques applied to rodent monoclonal antibodies.
  • 'Humanization' process to create therapeutic antibodies.

Main Results:

  • Humanized antibodies demonstrate improved pharmacokinetic properties.

Related Experiment Videos

  • Reduced immunogenicity compared to original rodent antibodies.
  • Successful clinical applications in treating various diseases.

    • Conclusions:

    • Protein engineering has significantly enhanced the therapeutic potential of antibodies.
    • Humanized antibodies represent a major advancement in treating infectious diseases, autoimmune disorders, and cancer.