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[Cytomegalovirus infection. A review]
K K Hansen1, V Backer, P Skinhøj
1Infektionsmedicinsk afdeling, Hvidovre Hospital, København.
Ugeskrift for Laeger
|August 30, 1993
Summary
Human cytomegalovirus (CMV) is a common congenital infection causing birth defects and a serious opportunistic infection in immunocompromised individuals. Effective antiviral treatments like ganciclovir are available for CMV disease.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Context:
- Human cytomegalovirus (CMV) is a prevalent herpesvirus infection.
- Previously underestimated, CMV is now recognized as a significant cause of congenital infections and birth defects.
- It is also a major opportunistic pathogen in immunocompromised patients, leading to severe illness and mortality.
Purpose:
- To highlight the evolving understanding of human cytomegalovirus (CMV) as a significant human pathogen.
- To emphasize the dual role of CMV as a congenital infection and an opportunistic infection.
- To underscore the importance of laboratory diagnosis and effective antiviral treatment for CMV disease.
Summary:
- CMV is an enveloped DNA virus belonging to the herpes family.
- Seroprevalence data, such as 50%-60% in Danish blood donors, indicate widespread exposure, influenced by demographic and behavioral factors.
- Diagnosis of primary or reactivated CMV infection warrants laboratory evaluation, as antiviral therapies like ganciclovir and foscarnet are effective.
Impact:
- Increased awareness of CMV's impact on congenital health and immunocompromised populations.
- Promotes timely diagnosis and intervention for CMV infections.
- Highlights the effectiveness of antiviral chemotherapy in managing CMV disease, improving patient outcomes.