[Antimycotic agents. 20. Bioisoteric 6-arylpyrimidine derivatives]

Condensation of N-(2-hydroxyethyl)-N-methylguanidine-sulfate (1) with the beta-diketones 4a-e bearing 1-aryl substituents leads to the bioisosteric 2-[(2-hydroxyethyl)-methylamino]-6-arylpyrimidines 5a-e. Compounds 5a-c exhibit significant antimycotic in vivo and in vitro activities.