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Unexpected hemorrhage related to acquired coagulopathies is a serious threat to many critically ill patients. The critical care nurse must possess a thorough knowledge of the basic coagulation process and the pathophysiology of common acquired coagulopathies. This article reviews the coagulation process and the conditions associated with acquired coagulopathies including vitamin K deficiency, liver disease, and renal disease. Also reviewed are common factors that contribute to the development of acquired coagulopathies, such as total parenteral nutrition (TPN) and antibiotics.
Unexpected hemorrhage related to acquired coagulopathies is a serious threat to many critically ill patients. The critical care nurse must possess a thorough knowledge of the basic coagulation process and the pathophysiology of common acquired coagulopathies. This article reviews the coagulation process and the conditions associated with acquired coagulopathies including vitamin K deficiency, liver disease, and renal disease. Also reviewed are common factors that contribute to the development of acquired coagulopathies, such as total parenteral nutrition (TPN) and antibiotics.