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[Tuberculosis as risk factor for venous thrombosis]
S Suárez Ortega1, J Artiles Vizcaíno, I Balda Aguirre
1Servicio de Medicina Interna, Complejo Hospitalario Las Palmas Norte (Hospital El Pino y El Sabinal), Gran Canaria.
Anales De Medicina Interna (Madrid, Spain : 1984)
|August 1, 1993
Summary
Advanced pulmonary tuberculosis increases the risk of deep venous thrombosis, particularly in HIV-negative individuals. Early detection and heparin prophylaxis are crucial for managing this serious complication.
Area of Science:
- Internal Medicine
- Pulmonology
- Hematology
Background:
- Deep venous thrombosis (DVT) is a serious condition that can arise from various factors.
- Pulmonary tuberculosis (PTB) is a significant infectious disease with potential systemic complications.
- Understanding the interplay between PTB and thrombotic events is crucial for patient management.
Observation:
- Three patients with advanced pulmonary tuberculosis developed deep venous thrombosis over a two-year period.
- One patient experienced a fatal outcome, likely due to thromboembolic complications.
- The remaining two patients had satisfactory outcomes after identifying potential tuberculosis-related triggers for venous thrombosis.
Findings:
- Advanced pulmonary tuberculosis is identified as a risk factor for venous thrombosis in HIV-negative patients.
- A high frequency of antiphospholipid antibodies was noted in tuberculosis patients.
- A potential link between antiphospholipid antibodies and Protein S deficiency was observed.
Implications:
- Avoidance of deep venous catheters is recommended in patients with advanced pulmonary tuberculosis.
- Prophylactic heparin therapy may be valuable in preventing venous thrombosis and its complications.
- Further research into the prothrombotic mechanisms in tuberculosis is warranted.