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[Tuberculosis as risk factor for venous thrombosis]

S Suárez Ortega1, J Artiles Vizcaíno, I Balda Aguirre

  • 1Servicio de Medicina Interna, Complejo Hospitalario Las Palmas Norte (Hospital El Pino y El Sabinal), Gran Canaria.

Anales De Medicina Interna (Madrid, Spain : 1984)
|August 1, 1993
PubMed
Summary

Advanced pulmonary tuberculosis increases the risk of deep venous thrombosis, particularly in HIV-negative individuals. Early detection and heparin prophylaxis are crucial for managing this serious complication.

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Area of Science:

  • Internal Medicine
  • Pulmonology
  • Hematology

Background:

  • Deep venous thrombosis (DVT) is a serious condition that can arise from various factors.
  • Pulmonary tuberculosis (PTB) is a significant infectious disease with potential systemic complications.
  • Understanding the interplay between PTB and thrombotic events is crucial for patient management.

Observation:

  • Three patients with advanced pulmonary tuberculosis developed deep venous thrombosis over a two-year period.
  • One patient experienced a fatal outcome, likely due to thromboembolic complications.
  • The remaining two patients had satisfactory outcomes after identifying potential tuberculosis-related triggers for venous thrombosis.

Findings:

  • Advanced pulmonary tuberculosis is identified as a risk factor for venous thrombosis in HIV-negative patients.

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  • A high frequency of antiphospholipid antibodies was noted in tuberculosis patients.
  • A potential link between antiphospholipid antibodies and Protein S deficiency was observed.

    • Implications:

    • Avoidance of deep venous catheters is recommended in patients with advanced pulmonary tuberculosis.
    • Prophylactic heparin therapy may be valuable in preventing venous thrombosis and its complications.
    • Further research into the prothrombotic mechanisms in tuberculosis is warranted.