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Scars and keloids

J C Murray1

  • 1Division of Dermatology, Duke University Medical Center, Durham, North Carolina.

Dermatologic Clinics
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Preventing abnormal wound responses like hypertrophic scars and keloids is crucial. Treatment varies, with surgery and radiation showing the lowest recurrence rates for keloids.

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Area of Science:

  • Dermatology
  • Wound Healing
  • Plastic Surgery

Background:

  • Abnormal wound responses, including hypertrophic scars and keloids, cause significant disfigurement and symptoms.
  • There is a lack of consensus in the literature regarding optimal therapeutic strategies for these conditions.
  • Few prospective, blinded studies exist to compare different treatment options.

Purpose of the Study:

  • To review and summarize current therapeutic approaches for abnormal wound responses.
  • To highlight the importance of prevention in predisposed individuals.
  • To compare the clinical course and treatment outcomes of hypertrophic scars versus keloids.

Main Methods:

  • Literature review of studies on abnormal wound response therapies.
  • Analysis of reported treatments including surgical correction, intralesional corticosteroid injection, pressure therapy, cryotherapy, and topical treatments.

Related Experiment Videos

  • Examination of recurrence rates for different keloid treatment modalities.

    • Main Results:

    • Prevention of stimuli that promote abnormal wound responses is widely agreed upon as essential.
    • Hypertrophic scars can be surgically corrected, and other treatments like intralesional corticosteroids, pressure therapy, and cryotherapy may be beneficial.
    • Keloids have a distinct clinical course compared to hypertrophic scars.
    • Combination therapy of surgery and radiation demonstrates the lowest recurrence rates for keloids.
    • While intralesional steroids may help some keloids, surgical excision followed by adjuvant therapy is key to minimizing recurrence.

    Conclusions:

    • Careful selection of treatment based on the specific lesion is necessary.
    • Preventative measures are paramount for individuals at risk of abnormal wound healing.
    • Combined surgical and radiation therapy offers the best outcomes for keloid management, emphasizing complete tissue removal and wound care to prevent recurrence.