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Progression of amiodarone induced cataracts
1Department of Ophthalmology, Veterans Administration Hospital, San Francisco, Calif.
Documenta Ophthalmologica. Advances in Ophthalmology
|January 1, 1993
Summary
Long-term amiodarone hydrochloride use can cause or worsen anterior subcapsular lens opacities. Despite subtle visual impairment, this antiarrhythmic drug remains a vital treatment option.
Area of Science:
- Ophthalmology
- Cardiology
- Pharmacology
Background:
- Amiodarone hydrochloride is a potent antiarrhythmic medication.
- Anterior subcapsular lens opacities were initially observed in patients treated with amiodarone.
- Long-term effects of amiodarone on vision require further investigation.
Purpose of the Study:
- To evaluate the progression of anterior subcapsular lens opacities in patients treated with amiodarone over a ten-year period.
- To assess the impact of these opacities on visual function.
Main Methods:
- A longitudinal study of fourteen patients treated with amiodarone.
- Ophthalmological examinations including Snellen visual acuity and contrast sensitivity measurements with and without glare.
- Comparison of findings over a ten-year interval.
Main Results:
- All fourteen patients who continued amiodarone treatment showed development or progression of anterior subcapsular lens opacities.
- No decrease in Snellen visual acuity was observed.
- Subtle visual impairment was detected through contrast sensitivity testing, particularly with glare.
Conclusions:
- Continuous amiodarone hydrochloride treatment is associated with the development and progression of anterior subcapsular lens opacities.
- While visual acuity is maintained, contrast sensitivity is affected, indicating subtle visual impairment.
- The observed visual changes do not contraindicate the use of amiodarone, a potentially life-saving drug.