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In vitro interaction between clindamycin and trimethoprim in combination on staphylococci
W el-Baz1, T Abd-el Hamid, A Tantawi
1Department of Medicine, Ain-Shams University, Cairo, Egypt.
International Journal of Clinical Pharmacology Research
|January 1, 1993
Abstract:
The in-vitro interaction between clindamycin and trimethoprim was tested on 10 staphylococcal clinical isolates by the checkerboard technique and by the time-kill curve. Indifference was demonstrated against seven of these strains and antagonism against three. The clindamycin/trimethoprim combination is of no value if the purpose of the combination is to obtain synergy against staphylococci. However, the combination is useful against mild polymicrobial infections due to Gram-positive aerobes, anaerobes and Enterobacteriaceae.