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Hindlimb and lung lymph flows during prolonged exercise

G Coates1, H O'Brodovich, G Goeree

  • 1Department of Radiology, McMaster University, Hamilton, Ontario, Canada.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 1, 1993
PubMed
Summary
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Exercise significantly increases hindlimb lymph flow (QL) through muscle massage and lung QL via increased vascular area. Both show steady-state increases due to elevated pressure and surface area during exercise.

Area of Science:

  • Physiology
  • Exercise Physiology
  • Lymphatic System Dynamics

Background:

  • Understanding how exercise impacts fluid dynamics in different circulatory systems is crucial for sports science and medicine.
  • Previous research has focused on systemic responses, but specific lymphatic flow (QL) changes in hindlimbs and lungs during exercise require further investigation.

Purpose of the Study:

  • To investigate the effects of 2 hours of exercise on hindlimb and lung lymph flow (QL) and protein concentration in sheep.
  • To differentiate the mechanisms driving early and steady-state QL responses during exercise.

Main Methods:

  • Sheep were instrumented with catheters for hindlimb lymph node efferent duct and chronic lung lymph collection.
  • Animals underwent treadmill exercise at 2.5-3.0 km/h for up to 2 hours.

Related Experiment Videos

  • Measurements included cardiac output, vascular resistance, pressures, QL, and lymph-to-plasma protein concentration ratios.

    • Main Results:

    • Cardiac output doubled, while pulmonary and systemic vascular resistance decreased significantly during exercise.
    • Hindlimb QL showed an immediate fivefold increase, attributed to muscle massage, and a later steady-state increase.
    • Lung QL doubled, with steady-state increases in both systems linked to increased microvascular surface area and pressure.

    Conclusions:

    • The rapid increase in hindlimb QL during exercise is primarily due to a massaging effect of working muscles.
    • Sustained increases in QL in both lung and hindlimb during exercise are driven by enhanced microvascular surface area and pressure.
    • Increased vascular surface area appears to be the predominant factor influencing lung QL during exercise.