Observations on the treatment and diagnosis of open pyometra in the bitch (Canis familiaris)

Eight bitches presenting with vaginal discharges were diagnosed as having open pyometra, as assessed by ultrasonographic, radiographic, haematological and clinical investigation. Plasma progesterone was assessed before treatment with prostaglandin F2 alpha (Dinoprost) and three of the bitches had low concentrations. Each bitch was given multiple injections of PGF2 alpha and monitored during and after treatment. All bitches had basal progesterone concentrations after treatment and the uterine diameters were markedly reduced by that time. One bitch has subsequently produced a litter of seven pups. Five of six bitches that were subjected to ovariohysterectomy 1-2 months later had normal uteri, although one had caseated areas in the uterine wall.