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Related Experiment Videos

Changes in diabetic urinary transferrin excretion after moderate exercise

J C Konen1, J H Summerson, Z K Shihabi

  • 1Department of Family and Community Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157.

Medicine and Science in Sports and Exercise
|October 1, 1993
PubMed
Summary

Exercise challenges reveal increased urinary transferrin and albumin excretion in diabetic patients. Measuring urinary transferrin may offer a more sensitive indicator of renal abnormalities in diabetes.

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Area of Science:

  • Nephrology
  • Endocrinology
  • Exercise Physiology

Background:

  • Microalbuminuria after exercise is a potential marker for diabetic kidney disease.
  • The sensitivity of urinary protein markers to moderate exercise needs further investigation.

Purpose of the Study:

  • To compare urinary transferrin and albumin excretion changes after moderate exercise in diabetic and non-diabetic individuals.
  • To assess the sensitivity of urinary transferrin excretion ratio (UTER) versus urinary albumin excretion ratio (UAER) post-exercise.

Main Methods:

  • Eight adults with insulin-dependent diabetes mellitus and eight healthy controls underwent a 20-minute moderate-intensity treadmill exercise test.
  • Urinary transferrin and albumin excretion ratios were measured before and after the exercise challenge.

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Main Results:

  • Nondiabetic subjects showed no significant increase in UTER or UAER.
  • Diabetic subjects exhibited a significant increase in UTER (207%) and UAER (209%) post-exercise.
  • UTER increase correlated with exercise intensity, while UAER increase was less dependent on exercise duration.

Conclusions:

  • Moderate exercise significantly increases urinary protein excretion in diabetic patients.
  • Urinary transferrin excretion may be a more sensitive biomarker than albumin for detecting exercise-induced renal changes in diabetes.