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Bioavailability of selenium from selenium-enriched garlic

C Ip1, D J Lisk

  • 1Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263.

Nutrition and Cancer
|January 1, 1993
PubMed
Summary
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Selenium-enriched garlic effectively restores liver selenoenzyme activity, demonstrating potent nutritional and anticancer properties comparable to sodium selenite. This suggests its efficacy in cancer chemoprevention is not mediated by thyroid hormone imbalance.

Area of Science:

  • Biochemistry
  • Nutritional Science
  • Cancer Research

Background:

  • Selenium-enriched garlic previously showed superior mammary cancer prevention in animal models.
  • Nutritional bioavailability of selenium from enriched garlic requires evaluation using selenoenzyme biomarkers.

Purpose of the Study:

  • To assess the nutritional bioavailability of selenium from selenium-enriched garlic.
  • To evaluate the impact of selenium-enriched garlic on liver selenoenzyme activity and thyroid hormone conversion.
  • To investigate the potential anticancer mechanisms of selenium-enriched garlic.

Main Methods:

  • Rats were fed a selenium-deficient diet to deplete glutathione peroxidase and type I 5'-deiodinase.
  • Supplementation with nutritional levels of selenium was provided via sodium selenite or selenium-enriched garlic.

Related Experiment Videos

  • Enzyme activity was measured in time-course repletion and dose-response experiments.

    • Main Results:

    • Selenium-enriched garlic effectively restored both glutathione peroxidase and type I 5'-deiodinase activity, similar to sodium selenite.
    • Both time-course and dose-response experiments confirmed the comparable efficacy of selenium from garlic and selenite.
    • High intake of selenium-enriched garlic did not alter type I 5'-deiodinase activity, indicating no T4-to-T3 imbalance.

    Conclusions:

    • Selenium in selenium-enriched garlic possesses potent nutritional and anticancer efficacy.
    • The bioavailability of selenium from enriched garlic is comparable to that from sodium selenite.
    • The anticancer effect of selenium-enriched garlic is unlikely to be due to modulation of the T4-to-T3 ratio.