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Synthesis and biological activity of 2-substituted analogues of 2'-deoxy-2'-fluoroadenosine
1Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Nucleic Acids Symposium Series
|January 1, 1993
Abstract:
Reaction of 2-iodo-6-methoxypurine 2'-deoxy-2'-fluororiboside with ammonia in methanol gave 2-iodo-adenosine derivative 2 in 69% yield. Treatment of 2 with nucleophiles gave 2-substituted analogues of 2'-deoxy-2'-fluoroadenosine. A new 2'-deoxy-2,2'-difluoroadenosine was also prepared by way of quaternary salt 4.