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Enzyme aided regio-selective acylation and deacylation of nucleosides
1Department of Applied Chemistry, Faculty of Engineering, Ehime University, Matsuyama, Japan.
Nucleic Acids Symposium Series
|January 1, 1993
Abstract:
Selective protection and deprotection of 5-fluorouridine and 5-fluoro-2'-deoxy-uridine derivatives have been studied by enzymatic esterification in organic solvents and enzymatic hydrolysis. Different selectively protected products could be prepared by using different enzymes. This provides an efficient method for selective protection of nucleosides.