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Retinal lesions in septicemia

M Neudorfer1, Y Barnea, O Geyer

  • 1Ophthalmology Department, Tel-Aviv Sourasky Medical Center, Israel.

American Journal of Ophthalmology
|December 15, 1993
PubMed
Summary
This summary is machine-generated.

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Septicemia, a severe bloodstream infection, is significantly associated with specific retinal lesions like hemorrhages and Roth's spots. Routine eye exams are recommended for septicemic patients to detect these critical findings.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Septicemia is a life-threatening condition with potential systemic complications.
  • Retinal manifestations of systemic diseases are crucial diagnostic indicators.
  • The specific association between septicemia and retinal lesions requires further elucidation.

Purpose of the Study:

  • To investigate the prevalence and types of retinal lesions in patients with septicemia.
  • To compare the incidence of retinal lesions in septicemic patients versus a control group.
  • To determine if specific organisms or infection sources correlate with retinal findings.

Main Methods:

  • A prospective controlled study design was employed.
  • 101 patients diagnosed with septicemia were included.

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  • Age- and gender-matched controls (99 patients) were used for comparison. Ophthalmoscopy was performed on all participants.

    • Main Results:

    • Retinal lesions (hemorrhages, cotton-wool spots, Roth's spots) were observed in 24% of septicemic patients versus 4% in controls (P = .0002).
    • No significant association was found between the type of organism or infection focus and the presence of retinal lesions.
    • Histological examination revealed cytoid bodies in the nerve fiber layer without inflammation.

    Conclusions:

    • A significant association exists between septicemia and the development of specific retinal lesions.
    • The findings underscore the importance of ophthalmoscopy in the routine evaluation of septicemic patients.
    • Early detection of retinal changes may aid in managing septicemia and its complications.