Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth factors and kidney development

M R Hammerman1, S A Rogers, G Ryan

  • 1George M. O'Brien Kidney and Urological Diseases Center, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110.

Pediatric Nephrology (Berlin, Germany)
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of prenatal sirolimus on cardiac rhabdomyomas and brain tubers.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2026
Same author

Benefits and complications of fetal and postnatal surgery for open spina bifida: systematic review and proportional meta-analysis.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

Single fetal demise in twin anemia-polycythemia sequence: perinatal outcome of surviving cotwin.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

Variability in antenatal prognostication of congenital diaphragmatic hernia by magnetic resonance imaging across the North American Fetal Therapy Network (NAFTNet).

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

Granular hydrogels as brittle yield stress fluids.

bioRxiv : the preprint server for biology·2025
Same author

Parent-Reported Usability of a Patient Portal-Based Asthma Care Tool for Parents of Children With Asthma.

Pediatric pulmonology·2025
Same journal

Impact of post-filter ionized calcium target range on circuit survival and citrate-related complications in pediatric continuous kidney replacement therapy.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Evaluation of the comparative efficacy and safety of obinutuzumab and other follow-up strategies after rituximab failure in refractory nephrotic syndrome.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Reno-ocular syndromes: pathophysiological mechanisms linking kidney and ocular disorders.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Implementation and evaluation of a quality improvement project to standardize food insecurity screening in a pediatric nephrology clinic.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Early-onset lipoprotein glomerulopathy in a 23-month-old boy with homozygous APOE Kyoto variant.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Vancomycin exposure in critically ill children undergoing high intensity continuous renal replacement therapy.

Pediatric nephrology (Berlin, Germany)·2026
See all related articles

Developing kidneys require specific growth factors. Insulin-like growth factors (IGF) and transforming growth factor-alpha (TGF-alpha) are produced by the metanephros and are essential for kidney development.

Area of Science:

  • Developmental biology
  • Nephrology
  • Molecular endocrinology

Background:

  • Kidney formation (renal organogenesis) relies on precise signaling.
  • Polypeptide growth factors play critical roles in embryonic development.
  • The roles of insulin-like growth factor (IGF) and epidermal growth factor (EGF)/transforming growth factor-alpha (TGF-alpha) families in kidney development require clarification.

Purpose of the Study:

  • To investigate the synthesis of IGF-I, IGF-II, EGF, and TGF-alpha during rat metanephric kidney development.
  • To determine the impact of blocking these growth factors on metanephric kidney growth and development.

Main Methods:

  • Developing rat metanephroi were cultured in vitro.
  • Synthesis of specific growth factors (IGF-I, IGF-II, EGF, TGF-alpha) was measured.

Related Experiment Videos

  • The effects of antibodies against these growth factors and the IGF-II receptor on organ development were assessed.

    • Main Results:

    • Metanephroi produced and secreted IGF-I, IGF-II, and TGF-alpha into the culture medium.
    • Epidermal growth factor (EGF) was not detected.
    • Inhibition of IGF-I, IGF-II, IGF-II receptor, or TGF-alpha using antibodies significantly impaired metanephric kidney growth and development.

    Conclusions:

    • Both insulin-like growth factor (IGF) family members and transforming growth factor-alpha (TGF-alpha) are endogenously produced by the developing metanephros.
    • These growth factors are crucial for promoting normal renal organogenesis.