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Quantification, Viability Assessment, and Visualization Strategies for Acinetobacter Biofilms
Published on: August 4, 2023
Acinetobacter meningitis
P Pearce1, H Ghuman, H Prabhakar
1Dept of Microbiology, Christian Medical College and Hospital, Ludhiana.
Indian Journal of Medical Sciences
|July 1, 1993
Summary
Acinetobacter calcoaceticus was found in 5.6% of meningitis cases. This strain showed high resistance to common antibiotics but remained susceptible to chloramphenicol.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Research
Background:
- Meningitis remains a significant cause of morbidity and mortality worldwide.
- Antimicrobial resistance is a growing global health concern, complicating treatment strategies.
Purpose of the Study:
- To investigate the prevalence and antimicrobial susceptibility of Acinetobacter calcoaceticus in cerebrospinal fluid (CSF) samples from meningitis cases.
- To identify effective antibiotic treatment options for meningitis caused by Acinetobacter calcoaceticus.
Main Methods:
- Analysis of 10,468 CSF samples collected from meningitis patients across various age groups between 1988 and 1991.
- Isolation and identification of bacterial pathogens, with a focus on Acinetobacter calcoaceticus.
- Antimicrobial susceptibility testing of isolated strains against a panel of antibiotics.
Main Results:
- Acinetobacter calcoaceticus was identified in 12 (5.6%) of 211 culture-confirmed meningitis cases.
- The isolated Acinetobacter calcoaceticus strains exhibited 100% resistance to ampicillin, cotrimoxazole, and tetracycline.
- Resistance to cephazolin, gentamicin, and kanamycin was observed in 50% of the strains, while 100% susceptibility to chloramphenicol was noted.
Conclusions:
- Acinetobacter calcoaceticus is an opportunistic pathogen that can cause meningitis.
- High levels of resistance to several commonly used antibiotics necessitate careful selection of antimicrobial therapy.
- Chloramphenicol demonstrated potent activity against the studied Acinetobacter calcoaceticus strains, suggesting its potential as a treatment option.
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