Transcriptional entrainment between master-slave genes via sister chromatid exchanges
1USC School of Medicine, Los Angeles 90033.
Medical Hypotheses
|September 1, 1993
Abstract:
The paper discusses a mechanism for the coordination of a differentiation path through activation of slave genes by transcriptional complexes (excitons) organised by master genes. Entrainment occurs when master-slave genes form partnerships of closely apposed entities. Sister chromatid exchanges provide the action necessary for successful entrainment. Although concerned mainly with normal hematopoietic (stem) cells, the model applies also to certain leukemic cells, regarding in particular retrodifferentiation back to the stem state followed by attenuation of malignancy.
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