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Related Experiment Videos

Colorectal carcinoma: a pathologic and immunopathologic study

M A Marcial1, A González, E Ramos Ruiz

  • 1Department of Pathology, Ramón Ruiz Arnau University Hospital, Bayamón, PR 00960-6032.

Puerto Rico Health Sciences Journal
|September 1, 1993
PubMed
Summary
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Lewis-related antigens Le(y) and Le(x) show promise as tumor markers in colorectal adenocarcinoma. Le(y) is a tumor-associated antigen, while Le(x) may indicate tumor aggressiveness and invasiveness.

Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • Lewis-related blood group antigens are expressed on erythrocytes and epithelial cells.
  • Their role in colorectal mucosa is debated: differentiation vs. tumor-associated antigens.

Purpose of the Study:

  • To prospectively investigate Lewis-related blood group antigens in colorectal adenocarcinoma.
  • To compare antigen expression in tumors versus adjacent non-neoplastic mucosa.

Main Methods:

  • Immunohematological studies and Lewis blood group determination from preoperative samples.
  • Immunoperoxidase staining of adenocarcinoma and adjacent mucosa for A, B, Le(a), Le(b), Le(x), and Le(y) antigens.
  • Correlation with tumor differentiation (grade) and Dukes stage.

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Main Results:

  • Le(a) (differentiation antigen) expressed in 82% of non-neoplastic mucosa.
  • Le(y) (tumor-associated antigen) detected in 77% of carcinomas vs. 18% of normal mucosa.
  • Le(x) found in 55% of carcinomas; virtually absent in non-invasive tumors.

Conclusions:

  • Le(y) expression is significantly increased in colorectal cancer, suggesting its utility as a tumor marker.
  • Le(x) expression correlates with tumor aggressiveness and pericolic tissue invasion.
  • Lewis antigens offer potential as biomarkers in colorectal adenocarcinoma.