[Amiodarone-induced skin pigmentation]

Amiodarone (Cordarone) is used in the treatment of cardiac arrhythmias. A blue-grey skin pigmentation appears after long term use or a high concentration of amiodarone. Two cases are described. Histopathological findings of skin punch biopsies from the face showed collections of yellow-brown granula pigment within histiocytes throughout the dermis. Sunlight initiates accumulation of the pigment. It is recommended to use sunprotection to avoid the pigmentation.