[Effect of superoxide dismutase on experimental allergic uveitis]

¹Zhongshan Ophthalmic Center, Sun Yat-Sen University of Medical Sciences, Guangzhou, China.

|June 1, 1993

Abstract:

In this study, experimental allergic uveitis (EAU) in guinea pigs was induced by an injection of bovine serum albumin (BSA) into the vitreous after having pre-immunized them intradermally with BSA plus incomplete Freund adjuvant, and the effect of superoxide dismutase (SOD) on EAU was observed. The result showed that, histopathologically, the phlogistic cell infiltration and exudation within the anterior ocular part of the SOD- treated animals reduced notably. It is suggested that SOD which can scavenge the free radical superoxide anion may alleviate the cellular reaction in the pathological process of uveitis.

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