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Non-calcifying Pindborg tumor with Langerhans cells
T Takata1, I Ogawa, M Miyauchi
1Clinical Laboratory, Hiroshima University School of Dentistry, Japan.
Summary
This study reports a rare calcifying epithelial odontogenic tumor (CEOT) lacking calcification. It highlights the presence of amyloid-like substances and Langerhans cells, offering new insights into CEOT pathology.
Area of Science:
- Oral pathology
- Odontogenic tumors
- Tumor biology
Background:
- Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic neoplasm.
- CEOTs are typically characterized by the presence of calcifications and amyloid-like material.
- This report details an unusual CEOT variant lacking typical calcification.
Observation:
- A CEOT occurred intraosseously in the maxillary canine and premolar region of a 58-year-old male.
- The tumor comprised epithelial cell islands within a fibro-myxoid stroma.
- Spherical eosinophilic bodies, identified as non-AA amyloid and non-keratin/basal lamina-like, were abundant.
Findings:
- Histochemical and immunohistochemical studies revealed the nature of the eosinophilic bodies.
- Some tumor nests showed S-100 protein positivity.
- Ultrastructural analysis identified Langerhans cells with characteristic features within the tumor.
Implications:
- This case expands the known spectrum of CEOT morphology.
- The paucity of calcification and presence of Langerhans cells may have prognostic significance.
- Further research is needed to understand the biological behavior and clinical implications of this CEOT variant.