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Weak male-driven molecular evolution in rodents

B H Chang1, L C Shimmin, S K Shyue

  • 1Center for Demographic and Population Genetics, University of Texas, Houston 77225.

Proceedings of the National Academy of Sciences of the United States of America
|January 18, 1994
PubMed
Summary
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The male-to-female mutation rate ratio (alpha m) in rodents is approximately 2, not extremely high as previously thought. This suggests DNA replication errors, not just male-driven mutation, are key, and generation time impacts mutation rates.

Area of Science:

  • Evolutionary Biology
  • Genetics
  • Molecular Biology

Background:

  • Previous studies suggested a very high male-to-female mutation rate ratio (alpha m), implying male-driven evolution.
  • This high alpha m was thought to be a significant factor in nucleotide substitution rates.

Purpose of the Study:

  • To accurately estimate the male-to-female mutation rate ratio (alpha m) in rodents.
  • To investigate the primary sources of mutation and the influence of generation time on mutation rates.

Main Methods:

  • Sequence data analysis of X and Y chromosome-linked zinc finger protein genes (Zfx and Zfy).
  • Estimation of germ cell division ratios from published oogenesis and spermatogenesis data.

Main Results:

Related Experiment Videos

  • Rodent alpha m was estimated to be approximately 2 (95% CI: 1-3), significantly lower than previously suggested.
  • The ratio of germ cell divisions per generation in rodents was estimated at approximately 2.
  • Rodent alpha m (approx. 2) is lower than that of higher primates (approx. 6), indicating generation-time effects.

    • Conclusions:

    • Errors in DNA replication appear to be the primary source of mutation in rodents.
    • The male-to-female mutation rate ratio (alpha m) is influenced by generation time, decreasing as generation time shortens.