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Synthesis and nonthrombogenicity of fluoroalkyl polyetherurethanes
T Kashiwagi1, Y Ito, Y Imanishi
1Department of Polymer Chemistry, Kyoto University, Japan.
Journal of Biomaterials Science. Polymer Edition
|January 1, 1993
Summary
New fluoroalkyl polyetherurethanes were synthesized and tested for biomedical applications. Increasing fluoroalkyl content reduced thrombus formation and protein adsorption, indicating potential for improved biocompatibility.
Area of Science:
- Polymer Chemistry
- Biomaterials Science
- Surface Chemistry
Background:
- Polyetherurethanes are widely used in biomedical devices due to their favorable mechanical properties.
- Enhancing the biocompatibility of polyetherurethanes is crucial for reducing adverse biological responses such as thrombosis and protein adsorption.
- Incorporating fluorinated segments into polymer structures can significantly alter surface properties and biological interactions.
Purpose of the Study:
- To synthesize novel polyetherurethanes functionalized with fluoroalkyl side chains.
- To investigate the effect of fluoroalkyl content and polymer molecular weight on the material's tensile properties and surface characteristics.
- To evaluate the in vitro biocompatibility of these novel materials by assessing thrombus formation, protein adsorption, platelet adhesion, and activation.
Main Methods:
- Synthesis of polyetherurethanes using N,N-di(hydroxyethyl)heptadecafluorooctyl-sulfonamide, 4,4'-disocyanatodiphenylmethane, and poly(tetramethylene glycol).
- Characterization of tensile properties by varying the fluoroalkyl chain extender content and poly(tetramethylene glycol) molecular weight.
- Surface analysis to determine water repellency.
- In vitro evaluation of thrombus formation, protein adsorption, platelet adhesion, and platelet activation.
Main Results:
- Successful synthesis of polyetherurethanes with fluoroalkyl side chains.
- Demonstrated strong water-repulsive surface properties of the fluoroalkyl polyetherurethanes.
- Observed a reduction in in vitro thrombus formation with increased fluoroalkyl chain extender content.
- Investigated the influence of material composition on protein adsorption, platelet adhesion, and platelet activation.
Conclusions:
- The synthesized fluoroalkyl polyetherurethanes exhibit promising surface properties and reduced thrombogenicity.
- The incorporation of fluoroalkyl substituents offers a viable strategy for enhancing the biocompatibility of polyetherurethane-based materials.
- These findings suggest potential applications for these novel materials in medical devices where reduced blood-contact activation is desired.