Related Experiment Videos
Isolated low HDL cholesterol. An insulin-resistant state
P Karhapää1, M Malkki, M Laakso
1Department of Medicine, Kuopio University Hospital, Finland.
Diabetes
|March 1, 1994
Summary
Men with isolated low high-density lipoprotein (HDL) cholesterol show increased insulin resistance. This study reveals higher insulin levels in low HDL and low HDL/high triglyceride groups compared to controls, indicating insulin resistance in isolated low HDL cholesterol.
Area of Science:
- Endocrinology
- Metabolic Syndrome
- Lipid Metabolism
Background:
- High very-low-density lipoprotein (VLDL) triglycerides and low high-density lipoprotein (HDL) cholesterol are linked to insulin resistance.
- Direct evidence for insulin resistance in isolated low HDL cholesterol is limited.
Purpose of the Study:
- To investigate insulin resistance and glucose metabolism in men with isolated low HDL cholesterol.
- To compare these parameters with control subjects and patients with both low HDL and high triglycerides.
Main Methods:
- Euglycemic glucose clamp technique and indirect calorimetry were employed.
- Three groups of men with normal glucose tolerance were studied: controls, isolated low HDL, and low HDL/high TG.
- Oral glucose tolerance tests (OGTT) were performed.
Main Results:
- No significant differences in glucose levels during OGTT between groups.
- Significantly higher fasting, 1-h, and 2-h insulin levels in the low HDL group compared to controls.
- Elevated insulin levels were also observed in the low HDL/high TG group compared to controls.
Conclusions:
- Isolated low HDL cholesterol in men is associated with insulin resistance.
- This finding suggests that low HDL cholesterol alone, independent of high triglycerides, can indicate impaired insulin sensitivity.