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The power of systematic genealogical study in familial Alzheimer disease
A C Bruni1, M P Montesi, I Rainero
1USSL 17, Lamezia Terme.
Italian Journal of Neurological Sciences
|April 1, 1993
Abstract:
Several kindreds (N, C, To and RB) with familial Alzheimer disease (FAD) from the same small area of Calabria are currently under study. Recently two of us (F.M. and L.F-S.) identified a family in Milan (FJ01) made up of 3 siblings whose parents were of Calabrian origin. Through a subsequent systematic or blanket genealogical study a link has been traced between kindreds To and FJ01. We discuss the relevance of these results to genetic studies.