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Severe phenytoin-induced bone marrow depression and agranulocytosis treated with human recombinant
A Rawanduzy1, A Sarkis, R L Rovit
1Department of Neurological Surgery, St. Vincent's Hospital and Medical Center of New York, New York.
Journal of Neurosurgery
|July 1, 1993
Abstract:
An unusual instance of severe and potentially lethal depression of the bone marrow is described as a result of the administration of phenytoin for seizure prophylaxis. The patient was treated successfully by prompt cessation of phenytoin and intravenous administration of human recombinant granulocyte-macrophage colony-stimulating factor.