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Optimal methods for identifying Clostridium difficile infections

D N Gerding1, J S Brazier

  • 1Infectious Disease Section, Veterans Affairs Medical Center, Minneapolis, Minnesota.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 1, 1993
PubMed
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Diagnosing Clostridium difficile infection requires balancing sensitive C. difficile cultures with specific toxin assays. Toxin testing is crucial for accurate diagnosis and appropriate patient treatment.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Clinical Microbiology

Background:

  • The diagnosis of symptomatic Clostridium difficile infection (CDI) is debated, centering on whether organism detection or toxin detection is sufficient.
  • C. difficile cultures are highly sensitive, while cytotoxin assays are highly specific for detecting CDI.