Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Digoxin intoxication due to unadjusted loading dose in renal failure]

H Seligmann1, D Ezra

  • 1Clinical Pharmacology Unit, Chaim Sheba Medical Center, Tel Hashomer.

Harefuah
|April 1, 1993
PubMed
Summary

Digoxin intoxication occurred in a patient with renal failure due to an unadjusted loading dose. Dosing regimens, including loading doses, require individual adjustment in renal failure patients due to altered drug distribution.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of preoperative anxiety and post-operative pain in patients undergoing dacryocystorhinostomy.

Revista espanola de anestesiologia y reanimacion·2021
Same author

Evaluation of preoperative anxiety and post-operative pain in patients undergoing dacryocystorhinostomy.

Revista espanola de anestesiologia y reanimacion·2021
Same author

101 <i>Dothideomycetes</i> genomes: A test case for predicting lifestyles and emergence of pathogens.

Studies in mycology·2020
Same author

First Report of Internal Black Rot Caused by Neoscytalidium dimidiatum on Hylocereus undatus (Pitahaya) Fruit in Israel.

Plant disease·2019
Same author

Factors Affecting the Response of Pomegranate Fruit to Alternaria alternata, the Causal Agent of Heart Rot.

Plant disease·2018
Same author

<i>Diaporthe</i> diversity and pathogenicity revealed from a broad survey of grapevine diseases in Europe.

Persoonia·2018

Area of Science:

  • Pharmacology
  • Nephrology
  • Clinical Toxicology

Background:

  • Digoxin is a cardiac glycoside commonly used for heart failure and arrhythmias.
  • Renal impairment significantly affects the pharmacokinetics of renally excreted drugs like digoxin.
  • Accurate digoxin dosing is crucial to avoid toxicity, especially in vulnerable patient populations.

Observation:

  • A case of digoxin intoxication is presented in a patient with renal failure.
  • The intoxication was attributed to an unadjusted digoxin loading dose.
  • The patient's renal failure led to altered digoxin distribution, increasing toxicity risk.

Findings:

  • The volume of distribution for digoxin is significantly reduced in chronic renal failure.
  • This reduction is linked to decreased tissue binding in the uremic state.

Related Experiment Videos

  • Both maintenance and loading doses of digoxin necessitate adjustment in renal failure.

    • Implications:

    • This case highlights the critical need for individualized digoxin dosing in patients with renal failure.
    • Failure to adjust loading doses can lead to severe digoxin toxicity.
    • Standard dosing protocols may be unsafe for patients with impaired renal function, necessitating personalized regimens.