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Updated: Jul 28, 2026
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Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Platelet thrombopathy in asthmatic patients with elevated immunoglobulin e
The Journal of Allergy and Clinical Immunology
|February 1, 1977
Summary
Asthma patients often show abnormal platelet aggregation, particularly those with high IgE levels. This allergic state may impact how platelets respond to various stimuli.
Area of Science:
- Immunology
- Hematology
- Pulmonology
Background:
- Platelet aggregation plays a crucial role in hemostasis and thrombosis.
- Asthma is a chronic inflammatory disease of the airways with complex pathophysiology.
- Allergic responses involve immune mediators that could potentially influence other physiological systems.
Purpose of the Study:
- To investigate platelet aggregation patterns in asthmatic patients.
- To determine if allergic factors correlate with platelet dysfunction in asthma.
- To explore the relationship between serum IgE levels and platelet responsiveness.
Main Methods:
- Controlled hospital setting with monitored drug and diet intake.
- Assessed second-wave platelet aggregation induced by various agents (epinephrine, ADP, collagen, thrombin).
- Measured pollen-specific radioallergosorbent (RAST) binding and serotonin/platelet factor 4 release.
Main Results:
- Abnormal platelet aggregation observed in 17 of 33 asthmatic patients.
- Significantly greater abnormal aggregation responses in patients with immunologically mediated asthma (high IgE) compared to controls.
- Higher pollen-specific RAST binding in patients with abnormal aggregation.
- Serotonin release mirrored abnormal aggregation; Platelet factor 4 release was decreased.
Conclusions:
- The allergic state in asthma may alter platelet membrane responsiveness.
- Elevated IgE levels are associated with impaired platelet aggregation in asthmatics.
- These findings suggest a link between allergic inflammation and platelet function.
