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Synthesis of 2-deoxy-D-galactose containing gangliosides in vivo
Y H Hwang1, G Kohla, C C Geilen
1Institut für Molekularbiologie und Biochemie, Freien Universität Berlin, Germany.
FEBS Letters
|July 19, 1993
Abstract:
Incorporation of 2-deoxy-D-galactose into the oligosaccharide moieties of different gangliosides of rat liver was examined. After intraperitoneal administration of 2-deoxy-D-galactose it was shown by GLC/MS analysis that this hexose analogue is metabolized and incorporated into all the gangliosides investigated, and predominantly into GM3 and GD3. In both of these gangliosides, 25-55% of the galactose residues were substituted by 2-deoxy-D-galactose. The epimer, 2-deoxy-D-glucose, was not detectable.