[Protective effect of vitamin E in total ischemia of isolated organs in rats]

The content of lipid peroxidation (LPO) products and fat-soluble vitamins in the isolated liver and heart of rats total ischemia of organs has been studied. Ischemia shifts the antioxidative balance towards LPO and formation of vitamin E metabolites of different destruction degree. It is shown that under such conditions the reactions of initial tocopherol reduction are possible in the case of preliminary introduction of physiological doses of vitamin E into the organism. In the myocardium the protective effect of tocopherol is much higher than in the liver.