[Effect of immobilization of analgin in polyvinyl alcohol on its mutagenicity in mice]

Mutagenicity of analgin in the tests for sperm head anomalies (SHA) and chromosome aberrations (CA) in bone marrow cells was studied in male mice Mus musculus. Analgin (40 micrograms) was injected intraperitoneally in 0.2 ml of aqueous solution or 0.01-5% solution of polyvinyl alcohol (PVA). Analgin was found to increase both SHA and CA frequencies. The drug immobilized in PVA also increased SHA and CA frequencies, though in less degree than non-immobilized one.