Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Studying brain development with quail-chick neural chimeras

N M Le Douarin1, K Tan, M Hallonet

  • 1Institut d'Embryologie Cellulaire et Moléculaire du CNRS et du Collège de France, Nogent-sur-Marne.

Kaibogaku Zasshi. Journal of Anatomy
|April 1, 1993
PubMed
Summary

Avian embryonic neural chimeras, created by grafting chick and quail tissues, reveal brain development. This technique illuminates the complex cell movements during medulla oblongata and cerebellum formation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Epidemiological characteristics of imported malaria cases in Chengdu City from 2016 to 2023].

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control·2025
Same author

Single-Cell Atlas of Immune Microenvironment in Orthodontic Tooth Movement.

Journal of dental research·2025
Same author

Psychotherapeutic modalities for phantom limb pain: a scoping review.

East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan·2025
Same author

'Is it time to standardise elective nephrostomies as day case procedures?'- a single-centre retrospective study.

Clinical radiology·2024
Same author

Correction: Progression of the pluripotent epiblast depends upon the NMD factor UPF2.

Development (Cambridge, England)·2024
Same author

Genitocrural Island Perforator Flap (GIP-Flap): An ideal surgical technique for covering uni- or bilateral vulvar loss tissue.

Annales de chirurgie plastique et esthetique·2023

Area of Science:

  • Developmental biology
  • Neuroscience
  • Embryology

Background:

  • Avian embryos provide a model for studying neural development.
  • Neural chimeras allow tracking cell origins and migration patterns.
  • Distinguishing quail and chick cells is crucial for chimera analysis.

Purpose of the Study:

  • To investigate the developmental processes of the avian brain, specifically the medulla oblongata and cerebellum.
  • To utilize quail-chick neural chimeras to map cell migration and morphogenetic movements.
  • To understand the ontogeny of complex brain structures in birds.

Main Methods:

  • Construction of avian embryonic neural chimeras by reciprocal grafting between chick and quail embryos.
  • Utilizing specific developmental stages (neurula or cephalic vesicle formation) before neural primordium vascularization.

Related Experiment Videos

  • Distinguishing quail and chick tissues using nuclear morphology and species-specific antibodies.

    • Main Results:

    • Successfully generated quail-chick chimeras, enabling long-term observation of grafted tissues.
    • Detailed mapping of morphogenetic movements and cell migrations during medulla oblongata development.
    • Elucidation of cellular contributions to cerebellar ontogeny through chimera analysis.

    Conclusions:

    • Avian neural chimeras are a powerful tool for dissecting complex brain development.
    • The study provides insights into the cellular basis of medulla oblongata and cerebellum formation.
    • This methodology facilitates understanding of avian neurodevelopmental processes.