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Synthesis of 3-oxa-5-alkylideneisocarbacyclins

K Kojima¹, S Amemiya

¹Medicinal Chemistry Research Laboratory, Sankyo Co., Ltd., Tokyo, Japan.

Chemical & Pharmaceutical Bulletin

|May 1, 1993

Abstract:

3-Oxa-5-methyleneisocarbacyclin (14a) and 3-oxa-5-ethylideneisocarbacyclin (19a) were synthesized. Compound 14a showed a potent antiplatelet aggregating activity, whereas 19a was inactive.

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